One corresponds roughly to the active site of Ec QueD (site 1), with the second site (site 2) more peripheral and solvent exposed, some 14 away and coordinated by the active site nucleophile, Cys23, an invariant Cys specific to QueD2s, Cys18 (this is a His in the other major cluster of QueD2 sequences), and two other poorly conserved residues derived from an adjacent subunit within a tetrameric ring
Triggiani M, Petraroli A, Loffredo S, et al
Human data are limited, so its real-world benefits and safety in people are not well established
I kind of got the impression that they were doing me a solid by putting my mind at ease, he told Undark and he said that he appreciated the additional details showing that the drug was safe and well-tolerated, at least in these small studies
Although there are no studies addressing biomarkers for increased risk of subsequent concussions, there is evidence to support the idea that cerebral vulnerability increases immediately following a concussion
